After five years of infatuation, Taiju Oki is about to confess to his love to fellow student Yuzuriha Ogawa. Suddenly a green light turns every human on the planet into stone and 3,700 years later, nature has taken over. Taiju manages to break free from his imprisonment. After finding the tree that Yuzuriha's petrified state is in, he soon meets up with his genius friend Senku Ishigami, who had awoken six months earlier. As the only two humans freed from stone, Senku seeks to rebuild civilization in this "stone world" using his knowledge of science and Taiju's brawn to help him develop a nital solution out of a miracle water made from bat guano that could possibly free people from their petrified state. After a year of development, the two friends manage to create a successful blend of "revival fluid".